Closed-loop On-demand Drug Delivery Micropump for Chronic Pain Management Applications
نویسنده
چکیده
We present a low power (0.66-51.31mW) electrochemical micropump capable of accurate delivery of a diverse assortment of liquid drug formulations within a wide dynamic range of flow rates (0.33 141.9μL/min) suitable for chronic pain management applications. This system rapidly responds to changes in regimen (<1sec) for on-demand control and has an electrochemically based dose tracking system that is capable of real-time tracking and confirmation of delivery. Tracking of bolus delivery down to 83nL (0.004% of reservoir) was achieved. On demand delivery and dose tracking of Lidocaine HCl hydrate (20mg/mL dissolved in PBS) was demonstrated.
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تاریخ انتشار 2013